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Christina Applegate Reveals Unimaginable Pain from MS-Related Gastrointestinal Issues

Christina Applegate Reveals Unimaginable Pain from MS-Related Gastrointestinal Issues
  • PublishedMarch 19, 2025

Picture this: a Hollywood star grappling with the kind of pain that would send most folks running for the hills—Christina Applegate recently opened up about her harrowing experiences with multiple sclerosis, and let’s be honest, it’s as gut-wrenching as it sounds. Celebrating a year of her podcast “MesSy,” Applegate shared the shocking reality of her health struggles, revealing that she has been hospitalized over 30 times due to severe gastrointestinal symptoms, including relentless vomiting and diarrhea. Now, if that doesn’t make you cringe, you’re probably made of tougher stuff than I am.

Applegate, 53, believes these distressing symptoms are intricately linked to her MS, a chronic disease that can wreak havoc on the central nervous system and, as it turns out, the digestive system too. As she explained to her co-host Jamie-Lynn Sigler and an audience of listeners, the pain is “unimaginable” and often culminates in a bizarre bodily clash she dubs “The Fight Club.” Yes, you read that right—her body is apparently hosting its own version of a brawl every time her organs decide to throw a tantrum.

In a moment of relatable candor, Applegate encouraged others suffering from similar symptoms to talk to their doctors about organ motility issues—a polite way of saying that things might not be working as they should down there. Despite her neurologist’s insistence that such gastrointestinal problems aren’t typical for MS, she highlighted the odd coincidences cropping up in her own life and that of her podcast listener, Kelly. Apparently, misery loves company, and they share more than just symptoms; they share the frustration of being told they’re “not in the medical books.”

And here we are, left wondering: how many people must suffer in silence before the medical community broadens its understanding of MS? Applegate’s willingness to speak out about her experiences challenges conventional wisdom and urges us to rethink how we view chronic illnesses like MS. So, if you’re ever in the unfortunate position of experiencing a “double dragon” moment—let’s hope you have a trash can handy. Because if life gives you lemons, it might just come with a side of gastrointestinal distress.

Sources: Celebrity Storm and People Magazine, Johns Hopkins Medicine

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Written By
Sage Matthews

Sage Matthews is a creative journalist who brings a unique and thoughtful voice to the world of celebrity news. With a keen eye for trends and a deep appreciation for pop culture, Sage crafts stories that are both insightful and engaging. Known for their calm and collected demeanor, they have a way of bringing clarity to even the messiest celebrity scandals. Outside of writing, Sage is passionate about environmental sustainability, photography, and exploring new creative outlets. They use their platform to advocate for diversity, inclusivity, and meaningful change in the media landscape.